Marcus Rashford, Alexis Sanchez, Jesse Lingard, Eric Bailly, and Ashley Young all move to the bench, allowing Romelu Lukaku, Diogo Dalot, and others to step up.
Lindelof meanwhile has been rested completely and isn’t in the matchday squad.
For Fulham, Ranieri has brought in Luciano Vietto for Cyrus Christie.
Fulham: Sergio Rico, Odoi, Le Marchand, Ream, Babel, Chambers, Seri, Bryan, Vietto, Mitrovic, Schurrle.
Substitutes: Ryan Sessegnon, Kebano, Cairney, Ayite, Christie, Zambo, Ramirez.
Manchester United: de Gea, Dalot, Smalling, Jones, Shaw, Ander Herrera, Matic, Pogba, Mata, Lukaku, Martial.
Substitutes: Bailly, Sanchez, Rashford, Lingard, Young, Romero, McTominay.